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Updated: Jun 7, 2025

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration
Published on: May 31, 2018
Novel Emerging Mechanisms in Acetaminophen (APAP) Hepatotoxicity
Alejandro Hionides-Gutierrez1, Naroa Goikoetxea-Usandizaga2,3, Carlos Sanz-García1
1Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, Madrid, Spain.
Background:
Drug-induced liver injury represents a critical public health issue, marked by unpredictable and potentially severe adverse reactions to medications, herbal products or dietary supplements.
Aims:
Acetaminophen is notably a leading cause of hepatotoxicity, impacting over one million individuals worldwide.
Materials & Methods:
Extensive research has elucidated the intricate mechanisms driving APAP-induced liver injury, emphasising the significant roles of endoplasmic reticulum stress, oxidative stress, mitochondrial dysfunction and cell death.
Results:
These insights pave the way for innovative therapeutic strategies, including the use of magnesium, bile acids, microbiota modulation and mesenchymal stem cells.
Discussion & Conclusion:
This review explores into these pathological mechanisms, proposing viable therapeutic interventions for patients suffering from APAP-induced liver injury.
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