Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice.

Journal of cachexia, sarcopenia and muscle·2026

Same author

Targeted, receptor-mediated delivery of a masked d-amino acid cell-penetrating peptide for cell-specific phototoxicity.

The FEBS journal·2026

Same author

NanoBRET-based detection of ligand-receptor interactions at the neuropeptide FF receptor 1.

RSC advances·2026

Same author

Fatty acid regulation of feeding in <i>Caenorhabditis</i> elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Crystal Growth Kinetics of Na <sub><b>2</b></sub> CO <sub><b>3</b></sub> Hydrate Phases in the Na <sub><b>2</b></sub> CO <sub><b>3</b></sub> -NaOH-H <sub><b>2</b></sub> O System for Sustainable Soda Ash Production.

ACS omega·2026

Same author

Modulating food intake by nasal application of peptides targeting melanocortin 4 receptor and ghrelin receptor systems.

Brain communications·2026

Search research articles

Related Experiment Video

Updated: Jun 7, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Design and Biofunctionalization of Cloud Sponge-Inspired Scaffolds for Enhanced Bone Cell Performance.

Philipp Zimmermann¹, Peter Schulze¹, Annette G Beck-Sickinger²

¹Engineering Faculty, Leipzig University of Applied Sciences (HTWK), Karl Liebknecht Str. 134, D-04277 Leipzig, Germany.

ACS Applied Bio Materials

|November 16, 2024

Summary

Sponge-inspired porous scaffolds enhanced bone cell biocompatibility and signaling. MP-RGD peptide coating further improved performance, guiding future bone implant material design.

Keywords:

Clear Resin bone cells cyclic RGD mussel peptide MP porosity sponge-inspired scaffolds

More Related Videos

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

Related Experiment Videos

Last Updated: Jun 7, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Aging populations increase demand for bone implants due to higher musculoskeletal disease rates.
Porous scaffolds offer advantages over conventional implants, promoting tissue ingrowth.
Marine sponge skeletons inspire biomaterial design for optimized porous structures.

Purpose of the Study:

To design and fabricate cloud sponge-inspired porous scaffolds.
To biofunctionalize scaffolds with mussel-derived peptide MP-RGD for enhanced cell adhesion.
To evaluate the biocompatibility and cellular response to these novel scaffolds.

Main Methods:

3D printing of sponge-inspired scaffolds using Clear Resin.
Biofunctionalization of scaffolds with MP-RGD peptide.
In vitro cell culture assays using bone cells.
Assessment of cell biocompatibility and signaling.

Main Results:

Sponge-inspired scaffolds (square, octagon, hexagon cubes) showed higher biocompatibility than hollow/sphere designs.
MP-RGD peptide coating significantly enhanced bone cell signaling and performance.
Three of five MP-RGD-coated scaffolds demonstrated superior biochemical properties.

Conclusions:

Both scaffold structure and MP-RGD coating are critical for enhancing biocompatibility.
MP-RGD-coated, sponge-inspired scaffolds show promise for improved bone implant development.
This study provides a foundation for designing advanced biomaterials for bone regeneration.