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Suxamethonium chloride and malignant hyperpyrexia
British Journal of Anaesthesia
|April 1, 1986
Abstract:
Pure suxamethonium chloride does not produce in vitro contracture of skeletal muscle from swine which are susceptible to malignant hyperpyrexia (MH), but does induce MH in vivo. It is suggested that suxamethonium chloride induces MH because the fasciculations which it causes lead to an increase in the myoplasmic calcium concentration.
Insights
Suxamethonium chloride does not cause in vitro muscle contraction in susceptible swine. However, it triggers malignant hyperpyrexia in vivo, possibly due to increased myoplasmic calcium from muscle fasciculations.
Area of Science:
- Anesthesiology
- Pharmacology
- Veterinary Medicine
Background:
- Malignant hyperpyrexia (MH) is a severe pharmacogenetic disorder of skeletal muscle.
- Swine susceptible to MH exhibit distinct responses to anesthetic agents.
Purpose of the Study:
- To investigate the in vitro and in vivo effects of suxamethonium chloride on swine susceptible to malignant hyperpyrexia.
- To explore the mechanism by which suxamethonium chloride may induce MH.
Main Methods:
- In vitro contracture testing of swine skeletal muscle exposed to suxamethonium chloride.
- In vivo administration of suxamethonium chloride to assess MH response in susceptible swine.
Main Results:
- Pure suxamethonium chloride did not induce in vitro contracture in skeletal muscle from MH-susceptible swine.
- Suxamethonium chloride administration in vivo triggered malignant hyperpyrexia in MH-susceptible swine.
Conclusions:
- The in vitro findings suggest that suxamethonium chloride's direct effect on muscle is not the primary trigger for MH in swine.
- In vivo MH induction is likely mediated by indirect effects, such as fasciculations leading to increased myoplasmic calcium levels.