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Lymphocyte-based inflammatory markers: Novel predictors of significant coronary artery disease✰,✰✰

Dania A Bani Hani1, Jafar A Alshraideh1, Akram Saleh2

  • 1School of Nursing, the University of Jordan, Amman, Jordan.

Heart & Lung : the Journal of Critical Care
|November 16, 2024
PubMed

Insights

Novel inflammatory markers, such as the Systemic Inflammatory Response Index (SIRI), effectively predict severe coronary artery disease (CAD) in high-risk patients. These simple blood tests can improve cardiac risk assessment.

Area of Science:

  • Cardiology
  • Immunology
  • Biomarkers

Background:

  • Lymphocyte-based inflammatory indices like monocyte-to-lymphocyte ratio (MLR) are established coronary artery disease (CAD) predictors.
  • Novel indices including Systemic Inflammatory Index (SII), Systemic Inflammatory Response Index (SIRI), and Systemic Immune-Inflammation Index (SIIRI) integrate multiple immune cells for comprehensive inflammation assessment.
  • These newer markers may enhance cardiovascular outcome prediction.

Purpose of the Study:

  • To evaluate the predictive value of novel inflammatory markers for severe CAD in high-risk individuals.
  • To assess the ability of these markers to estimate pretest probability of critical coronary artery narrowing.

Main Methods:

  • Consecutive patients undergoing coronary angiography were enrolled.
  • Inflammatory markers were calculated from pre-procedural complete blood count results.
  • Severe CAD was defined as critical (>70%) stenosis in a major coronary artery; classification performance was analyzed using logistic regression.

Main Results:

  • The study included 363 patients, with 30% having severe CAD.
  • Univariate analysis showed MLR, SIRI, and SIIRI significantly predicted severe CAD.
  • Multivariate analysis identified SIRI as an independent predictor of severe CAD (OR = 1.98, p = 0.02).

Conclusions:

  • Novel inflammatory markers derived from routine blood tests predict severe CAD in high-risk populations.
  • These simple, cost-effective markers can potentially improve cardiac risk stratification.
  • SIRI shows particular promise as an independent predictor of severe CAD.
Abstract

Keywords:
Lymphocytescoronary artery diseaseinflammationinflammatory responserisk assessment

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