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Epigenetic regulation of TGF-β and vice versa in cancers - A review on recent developments

Ankit Naik1, Noopur Thakur1

  • 1Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Navrangpura, Ahmedabad 380009, Gujarat, India.

Biochimica Et Biophysica Acta. Reviews on Cancer
|November 16, 2024
PubMed

Insights

Epigenetic alterations critically influence cancer cell behavior by modifying Transforming Growth Factor-beta (TGF-β) signaling. Understanding these epigenetic mechanisms offers new therapeutic strategies for various cancers.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic mechanisms, including DNA methylation and histone modifications, play a vital role in regulating gene expression.
  • Transforming Growth Factor-beta (TGF-β) signaling is a key pathway implicated in cell growth, differentiation, and cancer progression.
  • Dysregulation of TGF-β signaling is frequently observed in various cancers, contributing to tumorigenesis and metastasis.

Purpose of the Study:

  • To review the intricate relationship between epigenetic modifications and TGF-β signaling in cancer research.
  • To highlight the impact of epigenetic alterations on TGF-β pathway activity and cancer cell behavior.
  • To explore potential therapeutic strategies targeting both epigenetic regulation and TGF-β signaling.

Main Methods:

  • Literature review of recent advancements in cancer epigenetics and TGF-β signaling.
  • Analysis of studies focusing on DNA methylation, histone modifications, and chromatin remodeling.
  • Examination of regulatory networks involving non-coding RNAs (lncRNAs, miRNAs) in cancer.

Main Results:

  • Epigenetic alterations significantly impact TGF-β signaling pathways in cancer.
  • Specific epigenetic modifications are linked to altered TGF-β activity in breast, lung, liver, prostate, and pancreatic cancers.
  • Complex regulatory networks involving lncRNAs and miRNAs are interconnected with TGF-β signaling in these cancers.

Conclusions:

  • Epigenetic regulation and TGF-β signaling are deeply intertwined in the development and progression of cancer.
  • Targeting both epigenetic mechanisms and TGF-β pathways holds promise for novel cancer therapies.
  • Further research into these interactions can lead to improved strategies for cancer prevention and treatment.
Keywords:
CancerEpigeneticsSMADsTGF-β

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