Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Potentiometry: Membrane Electrodes

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacological characterization and functional divergence of tyramine receptors PxTAR2 and PxTAR1A in the diamondback moth, Plutella xylostella.

Insect biochemistry and molecular biology·2026

Same author

Reversing diastolic dysfunction in diabetes: a mitochondrial quality control-centric pharmacological approach.

Acta diabetologica·2026

Same author

Genetic and pharmacological inhibition of the Kir2A channel in diamondback moth exhibits ovicidal activity.

Insect science·2026

Same author

Hyperglycemia-driven metabolic memory signaling destabilizes METTL1 to trigger inflammatory hypertrophy and fibrosis in diabetic cardiomyopathy.

Acta diabetologica·2026

Same author

USP4 modulates ZBP1 ubiquitination to regulate microglial PANoptosis and functional outcomes following traumatic brain injury.

Cell death and differentiation·2026

Same author

Protective Effects of Leonurine on Alcoholic Liver Injury Through Modulation of Oxidative Stress and JAK2-STAT3 Signaling.

Current issues in molecular biology·2026

Search research articles

Related Experiment Video

Updated: Jun 7, 2025

Gold Nanoparticle Modified Carbon Fiber Microelectrodes for Enhanced Neurochemical Detection

Gold Nanoparticle Modified Carbon Fiber Microelectrodes for Enhanced Neurochemical Detection

Published on: May 13, 2019

Electrochemical biosensors for dopamine.

Hang Zhu¹, Guifen Xu²

¹School of Pharmacy and Medical Technology, Putian University, Putian, Fujian 351100, China; Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine, Putian University, Putian, Fujian 351100, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|November 16, 2024

Summary

Detecting dopamine (DA) is crucial for diagnosing neurological disorders. This review focuses on practical electrochemical biosensors for accurate DA measurement in biological samples, overcoming common interferences.

Keywords:

Biological systems Dopamine Electrochemical biosensors Real-world applications Surface modifiers

More Related Videos

Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry

Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry

Published on: November 21, 2012

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

Related Experiment Videos

Last Updated: Jun 7, 2025

Gold Nanoparticle Modified Carbon Fiber Microelectrodes for Enhanced Neurochemical Detection

Gold Nanoparticle Modified Carbon Fiber Microelectrodes for Enhanced Neurochemical Detection

Published on: May 13, 2019

Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry

Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry

Published on: November 21, 2012

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

Area of Science:

Neuroscience
Analytical Chemistry
Biomedical Engineering

Background:

Dopamine (DA) is a critical neurotransmitter regulating cognition, emotions, and physiological functions.
Abnormal dopamine levels are implicated in neurodegenerative diseases like Parkinson's and Alzheimer's, and psychiatric conditions such as schizophrenia.
Accurate determination of dopamine is essential for diagnosing and managing these conditions.

Purpose of the Study:

To review practical electrochemical biosensors for dopamine detection.
To highlight methods that overcome challenges in biological sample analysis, such as interference from ascorbic acid and uric acid.
To focus on sensors suitable for real-world applications.

Main Methods:

Electrochemical studies using modified electrodes.
Surface modification techniques including coatings, conducting polymers, ionic liquids, nanomaterials, and inorganic complexes.
Analysis of dopamine in biological samples.

Main Results:

Electrochemical methods offer high sensitivity and selectivity for dopamine detection.
Electrode modification strategies effectively separate dopamine signals from interfering biomolecules.
Various surface modifiers enhance electrocatalytic activity towards dopamine.

Conclusions:

Electrochemical biosensors are promising tools for sensitive and selective dopamine detection.
Developing cost-effective and practical sensors is key for clinical translation.
This review provides an overview of applicable electrochemical biosensors for real-world dopamine monitoring.