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Altered expression of Csnk1a1p in Autism Spectrum Disorder in Iranian population: case-control study
Zahra Rahmani1, Dina Rahmani1, Marie Saghaeian Jazi2
1Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Scientific Reports
|November 16, 2024
Summary
This study found lower Csnk1a1p long non-coding RNA levels in children with autism spectrum disorder (ASD). Csnk1a1p shows potential as a diagnostic biomarker for ASD.
Area of Science:
- Molecular Biology
- Neuroscience
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) are crucial for gene regulation and cellular homeostasis.
- Dysregulated lncRNAs are implicated in psychiatric disorders, including autism spectrum disorder (ASD).
Purpose of the Study:
- To investigate the expression levels of specific lncRNAs (DISC2, Linc00945, Foxg1-as1, Csnk1a1p, Evf2) in blood samples from individuals with ASD.
- To evaluate the potential of these lncRNAs as biomarkers for ASD diagnosis.
Main Methods:
- Blood samples were collected from 21 individuals with ASD and 25 healthy controls.
- RNA extraction, cDNA synthesis, and quantitative real-time PCR were used to measure lncRNA expression.
- Receiver operating characteristic (ROC) curve analysis assessed biomarker potential.
Main Results:
- A significant decrease in Csnk1a1p lncRNA expression was observed in individuals with ASD compared to controls (P=0.0008).
- ROC analysis demonstrated Csnk1a1p's effectiveness in discriminating ASD patients from healthy individuals (AUC=0.837, P=0.000284).
- No significant correlation was found between Csnk1a1p levels and ASD comorbidities like ADHD or intellectual disability.
Conclusions:
- Csnk1a1p lncRNA may play a significant role in the pathophysiology of ASD.
- Csnk1a1p presents potential as a diagnostic and predictive biomarker for ASD.
- Csnk1a1p could be a future therapeutic target for ASD.
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