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The association between the stress hyperglycaemia ratio and mortality in cardiovascular disease: a meta-analysis and

Harriet Esdaile1, Shaila Khan2, Jamil Mayet3

  • 1Faculty of Medicine, Department of Metabolism, Digestion and Reproduction, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, UK. h.esdaile@imperial.ac.uk.

Cardiovascular Diabetology
|November 16, 2024
PubMed

Insights

A high stress hyperglycaemia ratio (SHR) significantly increases the risk of all-cause mortality in patients hospitalized for cardiovascular events like heart attack and stroke. This finding holds true regardless of diabetes status or follow-up duration.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • A raised stress hyperglycaemia ratio (SHR) is linked to increased all-cause mortality.
  • SHR may be a better predictor of mortality than absolute glucose levels.
  • This meta-analysis examines SHR's association with mortality in common cardiovascular conditions.

Conclusions:

  • Elevated SHR is a significant risk factor for all-cause mortality post-myocardial infarction and ischemic stroke.
  • Further research is needed to establish SHR reference values and explore relative hypoglycemia.
  • Future interventions should consider targeting SHR over absolute glucose levels.
Abstract

Keywords:
CardiodiabetologyHyperglycaemiaInpatient ManagementMortalityStress hormones

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