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Transient receptor potential channels in viral infectious diseases: Biological characteristics and regulatory

Wen-Hui Qi1, Na Tang1, Zhi-Jing Zhao2

  • 1Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an, Shaanxi 710032, China; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, Air Force Medical University, Xi'an, Shaanxi 710032, China; Research Institution, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, China.

Journal of Advanced Research
|November 17, 2024
PubMed
Abstract

Insights

Transient receptor potential (TRP) channels are crucial in viral infections, affecting viral replication and host immunity. Understanding TRP channel roles offers new therapeutic strategies for viral diseases.

Area of Science:

  • Molecular Biology
  • Virology
  • Immunology

Background:

  • Viral infectious diseases present ongoing global health challenges.
  • Transient receptor potential (TRP) channels are increasingly recognized for their role in viral pathogenesis.
  • Disruptions in TRP channel-mediated calcium (Ca2+) homeostasis are linked to viral disease onset and progression.

Purpose of the Study:

  • To systematically review current knowledge on TRP channels in viral infections.
  • To elucidate the mechanisms underlying TRP channel involvement in viral diseases.
  • To propose future research avenues and therapeutic strategies.

Main Methods:

  • Literature review of recent advances in TRP channel research related to viral infections.
  • Analysis of TRP channel functions at the viral, host, and outcome levels.
  • Exploration of potential therapeutic applications of TRP channels.

Main Results:

  • TRP channels directly influence viral replication and biology.
  • TRP channels modulate host immune responses and inflammation.
  • TRP channel dysregulation contributes to pathological changes during viral infections.

Conclusions:

  • TRP channels play multifaceted roles in viral infectious diseases.
  • Targeting TRP channels presents a promising therapeutic approach for viral infections.
  • Further research is needed to fully understand and exploit TRP channel functions in antiviral strategies.
Keywords:
Antiviral immunityInflammatory stormTransient receptor potential channelsViral infectious diseasesVirus life cycle

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