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Related Experiment Video

Updated: Jun 7, 2025

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

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Published on: November 28, 2010

Oxysterols in tumor immune microenvironment (TIME).

Yuanxin Liu¹, Jie Qin¹, Xiaorui Li²

¹Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.

The Journal of Steroid Biochemistry and Molecular Biology

|November 17, 2024

Summary

Oxysterols, cholesterol oxidation products, modulate the tumor immune microenvironment by interacting with key receptors. This interaction influences immune cell behavior, offering potential for novel cancer immunotherapy strategies.

Keywords:

EBI2 LXR Oxysterol TIME Tumor

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Published on: August 28, 2018

Area of Science:

Biochemistry
Immunology
Oncology

Background:

Oxysterols are derived from cholesterol oxidation and impact cellular processes.
They interact with receptors like EBI2, LXR, and PXR, influencing signaling pathways.
These interactions are critical in the tumor immune microenvironment (TME).

Purpose of the Study:

To investigate the role of oxysterols in the tumor immune microenvironment.
To explore how oxysterols affect immune cell function and tumor development.
To identify oxysterols as potential therapeutic targets in cancer immunotherapy.

Main Methods:

Analysis of oxysterol interactions with cell membrane and nuclear receptors (EBI2, LXR, PXR).
Assessment of immune cell signaling pathways (proliferation, apoptosis, migration, invasion).
Evaluation of oxysterol effects on immune cell populations (macrophages, T cells, dendritic cells) within the TME.

Main Results:

Oxysterol-receptor interactions regulate immune cell signaling pathways.
Altered immune cell function (macrophages, T cells, dendritic cells) within the TME.
Specific oxysterols enhance T cell infiltration and activation, synergizing with anti-PD-1 therapy.

Conclusions:

Oxysterols significantly influence the tumor immune microenvironment.
Understanding oxysterol mechanisms can reveal new therapeutic targets for cancer.
Oxysterols present innovative strategies for enhancing tumor immunotherapy.