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Updated: Jun 7, 2025
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Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice
Published on: March 1, 2017
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Uveitis among people with multiple sclerosis: A systematic review and meta-analysis
Saeed Vaheb1, Mohammad Yazdan Panah2, Vahid Shaygannejad3
1Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Survey of Ophthalmology
|November 17, 2024
Summary
The overall prevalence of uveitis in people with multiple sclerosis (MS) is 1.1%. Intermediate uveitis is the most common type, affecting 0.6% of individuals with MS. Early diagnosis by specialists is crucial.
Area of Science:
- Ophthalmology
- Neurology
- Public Health
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- People with MS (pwMS) frequently experience ocular complications.
- Uveitis is a significant ocular complication associated with MS.
Purpose of the Study:
- To determine the overall prevalence of uveitis among pwMS.
- To identify the prevalence of different types of uveitis in pwMS.
- To synthesize existing research on MS-related uveitis through meta-analysis.
Main Methods:
- Systematic literature search across PubMed/MEDLINE, Scopus, EMBASE, and Web of Science (1990-2023).
- Meta-analysis of 12 selected studies involving 54,402 pwMS using R software.
- Random-effect model to calculate pooled prevalence and 95% confidence intervals.
Main Results:
- The pooled prevalence of uveitis in pwMS was 1.1% (95% CI: 0.6-1.7%).
- Intermediate uveitis was the most prevalent type, with a prevalence of 0.6% (95% CI: 0.2-1.0%).
- Significant heterogeneity was observed across studies (I² > 87%, p < 0.01).
Conclusions:
- Uveitis affects approximately 1.1% of people with MS.
- Intermediate uveitis is the most common subtype in this population.
- Prompt diagnosis and specialist management of uveitis in pwMS are essential.
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