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Updated: Jun 7, 2025

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
Published on: November 21, 2017
The association between body temperature and 28-day mortality in sepsis patients: A retrospective observational study
Wei Yang1, Dan Zhou1, Hui Peng1
1Department of General Practice, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong Province, China.
Objective:
This study explored the association between body temperature and 28-day septic ICU hospital mortality.
Design:
Retrospective cohort analysis.
Setting:
208 ICUs in the United States.
Patients Or Participants:
Sepsis patients from 2014-2015 eICU Collaborative Research Database.
Interventions:
Binary logistic regression models, Generalized Additive Model (GAM), Two-Piece Binary Logistic Regression Model.
Main Variables Of Interest:
Body temperature, 28-day inpatient mortality.
Results:
Nonlinear relationship observed; hypothermia (≤36.67 ℃) associated with increased mortality (adjusted OR = 0.74, 95% CI: 0.70-0.80, p < 0.0001).
Conclusions:
Hypothermia in sepsis correlates with higher mortality; rewarming's potential benefit warrants further exploration.
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