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Murine Fecal Isolation and Microbiota Transplantation

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Causal Link between Gut Microbiota and Infertility: A Two-sample Bidirectional Mendelian Randomization Study.

Jia-Xin Zhang¹, Qin-Lan Li¹, Xiao-Yan Wang²

¹Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Current Medical Science

|November 17, 2024

Summary

The gut microbiome influences reproductive health, with specific bacteria linked to infertility, PCOS, and other conditions. Uterine diseases significantly alter gut bacteria, suggesting a bidirectional relationship impacting reproductive system diseases.

Keywords:

Mendelian randomization epididymitis gut microbiota infertility orchitis ovarian sexual dysfunction uterine

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Area of Science:

Microbiome Research
Reproductive Medicine
Genetics

Background:

The gut microbiota plays a crucial role in overall health.
Emerging evidence suggests a link between gut dysbiosis and various diseases, including reproductive disorders.

Purpose of the Study:

To investigate the bidirectional causal associations between gut microbiota composition and a spectrum of reproductive system diseases.
To identify specific microbial taxa implicated in conditions such as infertility, PCOS, endometriosis, and others.

Main Methods:

A two-sample bidirectional Mendelian randomization (MR) analysis was employed.
This approach evaluated potential causal relationships between genetically predicted gut microbial abundance and reproductive diseases.

Main Results:

Sixty-one significant causal associations were identified between gut microbes and reproductive diseases.
Specific genera like Erysipelatoclostridium and Intestinibacter were linked to conditions like PCOS, endometriosis, male infertility, and sexual dysfunction.
Uterine diseases showed a greater impact on gut microbiota composition compared to ovarian diseases.

Conclusions:

A bidirectional causal relationship exists between the gut microbiota and infertility and associated reproductive diseases.
Understanding these microbial links offers new avenues for clinical investigation and therapeutic strategies for reproductive health disorders.