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Updated: Jun 20, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

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Published on: June 7, 2015

Injectable Hydrogels for Liver: Potential for Clinical Translation.

Ashwini Vasudevan^1,2, Doyel Ghosal³, Sita Ram Sahu⁴

¹Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, 110070, India.

Chemistry, an Asian Journal

|November 18, 2024

Summary

Injectable hydrogels offer minimally invasive delivery for cells and drugs. This review explores their design, delivery, and potential for liver regeneration, while addressing clinical translation challenges.

Keywords:

Injectable hydrogels clinical translation liver polymers

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Last Updated: Jun 20, 2026

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Published on: June 7, 2015

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Biomaterials Science
Regenerative Medicine
Drug Delivery

Background:

Injectable hydrogels are versatile biomaterials for minimally invasive delivery of therapeutic agents.
Current applications include wound dressings and tissue reconstruction, with emerging interest in liver disease treatment.

Purpose of the Study:

To review the design principles and delivery strategies of injectable hydrogels for liver regeneration.
To discuss the potential applications and clinical translation challenges of these hydrogels in liver disease.

Main Methods:

Literature review of injectable hydrogel design, fabrication, and application in liver regeneration.
Analysis of pre-clinical and clinical data regarding hydrogel efficacy and safety.
Discussion of challenges and potential solutions for clinical translation.

Main Results:

Injectable hydrogels show promise for encapsulating and delivering therapeutic payloads to the liver.
Pre-clinical studies demonstrate potential for facilitating liver regeneration and ameliorating injury.
Clinical efficacy for liver diseases is yet to be established, with several translation hurdles identified.

Conclusions:

Injectable hydrogels represent a promising therapeutic strategy for liver diseases, requiring further clinical validation.
Overcoming design, delivery, and regulatory challenges is crucial for successful clinical translation.
Continued research is needed to optimize hydrogel performance and safety for liver regeneration.