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Behavioral Analyses in Dark Agouti Rats Following Repeated Systemic Treatment With Fingolimod (FTY720).

Marie Jakobs1, Lisa Trautmann1, Martin Hadamitzky1

  • 1Institute of Medical Psychology and Behavioral Immunobiology, Center for Translational Neuro-Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Brain and Behavior
|November 18, 2024
PubMed
Summary

FTY720, an immunosuppressive drug, altered rat behavior by reducing movement and increasing freezing, but did not cause anxiety-like effects. Further clinical evaluation is needed for potential side effects.

Keywords:
adverse side effectsanxiety‐like behaviorfingolimod (FTY720)immunosuppressive drugs

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Experimental animal studies show immunosuppressive drugs cause neurobehavioral changes.
  • FTY720 is an immunosuppressive drug used for multiple sclerosis treatment.

Purpose of the Study:

  • To investigate behavioral alterations in rats following repeated administration of FTY720.
  • To determine if FTY720 induces anxiety-like behaviors or other neurobehavioral changes.

Main Methods:

  • Rats received repeated FTY720 administration.
  • Behavioral testing included open field, elevated plus maze, and dark/light tests.
  • FTY720 concentrations in brain regions and plasma corticosterone levels were measured.

Main Results:

  • FTY720 treatment reduced distance traveled and increased freezing behavior in rats.
  • Increased freezing time correlated with FTY720 levels in the amygdala and insular cortex.
  • No changes in plasma corticosterone indicated stress was not a confounding factor.

Conclusions:

  • FTY720 did not induce typical anxiety-like behaviors in healthy rats.
  • Behavioral effects observed differ from those of other immunosuppressive drugs.
  • Clinical monitoring for side effects of small-molecule immunosuppressive drugs is crucial.