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Platelet storage failure-Metformin as causative agent.

Larry J Dumont^1,2, Kathleen Kelly¹, Travis Nemkov³

¹Vitalant Research Institute, Denver, Colorado, USA.

|November 18, 2024

Summary

This summary is machine-generated.

Metformin use by platelet donors can cause stored platelet pH failures, impacting platelet quality. Further research is needed to assess medication effects on platelet storage and potential donor screening.

Keywords:

apheresis platelet lactic acidemia metabolomics metformin pH failure platelet storage

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Area of Science:

Transfusion Medicine
Biochemistry
Hematology

Background:

Apheresis platelets (APs) treated with pathogen reduction technology (PRT) exhibited pH < 6.2.
Platelet quality issues were observed in a donor taking metformin and other medications.

Observation:

Paired PRT-treated and untreated apheresis platelets (APs) from the same donor showed pH decline below 6.2 within 2 days.
High lactate generation rates were observed in both PRT-treated and untreated APs.
Metabolomic analysis indicated impaired energy metabolism pathways in PRT-treated platelets compared to untreated ones.

Findings:

Metformin significantly increased glycolysis in platelets in a dose-dependent manner, leading to decreased pH.
Pathogen reduction technology (PRT) was not identified as the primary cause of the observed lactic acid production.
Metformin is the likely cause of stored platelet pH failures in this donor.

Implications:

Metformin's impact on platelet storage necessitates further investigation.
Current donor deferral criteria may need reevaluation regarding metformin use.
Development of additional laboratory screening tools may be required to ensure platelet product safety.