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Updated: Jun 7, 2025

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
Published on: November 30, 2018
Crystal structure and the degradation products of Tenvermectin B
Zhen-Yu Wang1, Chun-Hui Wu2, Xiao-Han Ren1
1Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insect, College of Life Science, Huzhou University, Huzhou, China.
Abstract:
The purpose of this work was to investigate the crystal structure and degradant products (DPs) of tenvermectin B (TVM B). A suitable crystal of TVM B was obtained from a solvent system (MeOH:formamide:H2O = 2:5:2) and its absolute configuration was unambiguously established by single-crystal X-ray diffraction analysis. Meanwhile, a formamide-assisted crystallisation method for the purification of TVM B was developed. During the stress degradation studies of TVM B, four DPs (DPs 1-4) were prepared and characterised by MS and NMR. Among them, DP 2 and DP 3 have not been reported previously. In addition, the nematocidal activity of these DPs were evaluated.
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