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Updated: Jun 7, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Manganese(I)-Catalyzed Access to Enantioenriched Chiral Aziridine Phosphines
Chuang Ni1, Tizian-Frank Ramspoth1, Marta Castiñeira Reis2
1Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Abstract:
Herein, we present the first catalytic asymmetric nucleophilic addition of diarylphosphines to 2H-azirines, facilitated by a chiral Mn(I) complex. This method not only provides access to novel class of derivatives of the aziridine core - a structural motif recognized for its antitumor and antibacterial properties - but also introduces a phosphine moiety alongside the generation of an NH moiety within a strained three-membered ring. The discovery of this new Mn(I) complex that both enables the reaction and induces stereoselectivity is pivotal, as it underscores the significant potential of this earth-abundant metal in advancing asymmetric catalysis.
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