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Hormonal contraception and cancer.

J Drife, J Guillebaud

    British Journal of Hospital Medicine
    |January 1, 1986
    PubMed
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    Combined oral contraceptives may protect against endometrial and ovarian cancers by altering hormonal fluctuations. However, their impact on breast and cervical cancer development requires further investigation.

    Area of Science:

    • Gynecology
    • Oncology
    • Endocrinology

    Background:

    • The natural menstrual cycle involves hormonal fluctuations that can impact cancer development.
    • Hormonal therapies, such as combined oral contraceptives (COCs), alter these natural cycles.

    Purpose of the Study:

    • To investigate the influence of combined oral contraceptives on the risk of developing specific cancer types.
    • To clarify the uncertain effects of COCs on breast and cervical carcinomas.

    Main Methods:

    • Review of existing epidemiological studies and clinical data.
    • Analysis of hormonal profiles and cancer incidence rates in users versus non-users of COCs.

    Main Results:

    • Combined oral contraceptives demonstrate a protective effect against endometrial and ovarian cancers.
    Keywords:
    BiologyBreast Cancer--etiologyCancerCervical Cancer--etiologyContraceptionContraceptive AgentsContraceptive Agents, FemaleContraceptive Methods--side effectsDemographic FactorsDiseasesEndocrine SystemEndometrial Cancer--etiologyEnglandEuropeFamily PlanningHormonesIncidenceMeasurementMenstrual CycleMenstruationMortalityNeoplasmsNorthern EuropeOral Contraceptives, Combined--side effectsOral Contraceptives--side effectsOvarian Cancer--etiologyPhysiologyPopulationPopulation At RiskPopulation DynamicsReproductionReproductive Control AgentsResearch MethodologyUnited KingdomWales

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  • The association between combined oral contraceptive use and the risk of breast and cervical cancer remains inconclusive.

    • Conclusions:

    • Combined oral contraceptives offer significant protection for endometrial and ovarian cancer.
    • Further research is necessary to determine the definitive relationship between combined oral contraceptive use and breast and cervical cancer risk.