Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimal 24-hour movement behaviour compositions across trimesters and risk of hypertensive disorders of pregnancy: the Pregnancy 24/7 cohort study.

British journal of sports medicine·2026
Same author

Atraumatic Transdiaphragmatic Intercostal Hernia Following a Coughing Spell: A Case Report.

Cureus·2026
Same author

A case of acute necrotising encephalitis secondary to human herpesvirus 6 infection.

Lancet (London, England)·2026
Same author

SIV infection disrupts the spatial cellular and communication networks of pulmonary granulomas during SIV/Mtb co-infection.

bioRxiv : the preprint server for biology·2026
Same author

Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb coinfection in macaques.

JCI insight·2026
Same author

The Effect of Aerobic Exercise on Post-concussion Recovery in Athletes: A Narrative Review.

Cureus·2026

Related Experiment Video

Updated: Jul 9, 2026

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome
05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

6.5K

Atypical Sensory Loss Pattern in an Isolated Thalamic Stroke: A Case Report.

Mariam Tadros1, David Phrathep2,3, Emily Lewandowski1

  • 1Department of Physical Medicine and Rehabilitation, Lake Erie College of Osteopathic Medicine, Bradenton, USA.

Cureus
|November 18, 2024
PubMed
Summary

This case report highlights a rare instance where initial CT scans missed a thalamic stroke. Follow-up MRI was crucial for diagnosing this cerebrovascular accident, emphasizing the need for advanced imaging in subtle neurological cases.

Keywords:
atypical thalamic strokecerebrovascular accidentcomputed tomography imagingischemic strokemagnetic resonance imagingthalamic stroke

More Related Videos

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

1.8K
Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

1.8K

Related Experiment Videos

Last Updated: Jul 9, 2026

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome
05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

6.5K
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

1.8K
Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

1.8K

Area of Science:

  • Neurology
  • Radiology

Background:

  • Computed tomography (CT) is the primary diagnostic tool for suspected cerebrovascular accidents (CVAs).
  • Thalamic strokes often present with specific neurological deficits, including hemiparesis and sensory loss.

Observation:

  • A 51-year-old male presented with left-sided hemiparesthesia and incoordination.
  • Initial and follow-up brain CT scans were negative for acute abnormalities.
  • Magnetic resonance imaging (MRI) ultimately identified an ischemic incident in the right thalamus.

Findings:

  • The patient's presentation of pure hemiparesthesia without facial involvement was atypical for a thalamic lesion.
  • CT imaging failed to detect the early ischemic changes in the thalamus.

Implications:

  • This case underscores the limitations of CT in diagnosing subtle cerebrovascular accidents.
  • It highlights the critical role of MRI in cases with persistent or atypical neurological symptoms despite negative CT findings.
  • Emphasizes the importance of clinical correlation and considering advanced imaging for accurate diagnosis and timely intervention.