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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Natural Compounds and Cancer: Current Evidences.

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Natural compounds show promise for treating chronic diseases and cancer due to low toxicity and high bioavailability. This review highlights their potential against head and neck, glioblastoma, and gastrointestinal cancers.

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Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Natural compounds are increasingly recognized for their therapeutic potential in chronic diseases and cancer.
  • Key features include low toxicity and high bioavailability, making them attractive alternatives to conventional treatments.
  • These compounds exhibit significant in vitro antitumor activity through diverse mechanisms.

Discussion:

  • Mechanisms of action include reducing cell viability, inhibiting cell proliferation, inducing apoptosis, and causing cell cycle arrest.
  • The review focuses on natural compounds with potential applications in treating head and neck cancers, glioblastoma, and gastrointestinal cancers.
  • Evidence supports the efficacy of various natural agents against specific cancer types.

Key Insights:

  • Natural compounds offer a promising avenue for cancer therapy, particularly for difficult-to-treat malignancies.
  • Specific natural agents have demonstrated potent anti-cancer effects in preclinical studies.
  • Further research is warranted to translate these findings into clinical applications.

Outlook:

  • Future research should focus on identifying novel natural compounds and elucidating their precise mechanisms of action.
  • Clinical trials are essential to evaluate the safety and efficacy of these compounds in human patients.
  • Combination therapies involving natural compounds and conventional treatments may offer synergistic benefits.