Systemic inflammation and lymphocyte activation precede rheumatoid arthritis
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View abstract on PubMed
Summary
This summary is machine-generated.Researchers identified key immune changes during the pre-symptomatic phase of rheumatoid arthritis (RA). Understanding these early alterations in systemic inflammation and specific immune cells offers potential for novel interventions to prevent or delay autoimmune disease onset.
Area Of Science
- Immunology
- Autoimmune Diseases
- Systems Biology
Background
- Autoimmune diseases like rheumatoid arthritis (RA) have a subclinical phase.
- Understanding this pre-disease state is crucial for proactive management but is limited by a lack of biological insight.
- Identifying early immune alterations can reveal targets for intervention.
Purpose Of The Study
- To characterize the immune landscape during the at-risk period preceding clinical diagnosis of RA.
- To identify specific cellular and molecular changes that define the subclinical phase of RA.
- To provide tools for exploring this extensive multi-omics dataset.
Main Methods
- Cross-sectional and longitudinal multi-omics study of peripheral immune cells.
- Analysis of autoantibody-positive individuals at risk for RA.
- Identification of systemic inflammation markers, B cell and T cell populations, monocyte phenotypes, and CD4 T cell transcriptional signatures.
Main Results
- Systemic inflammation and proinflammatory-skewed B cells were identified.
- Expanded Tfh17-like cells and epigenetic bias in naive T cells were observed.
- Monocytes resembled synovial macrophages, and CD4 T cell features mimicked those affected by abatacept in RA patients.
Conclusions
- The at-risk state for RA exhibits significant immune alterations prior to clinical diagnosis.
- These findings provide a deeper understanding of RA pathogenesis.
- Targeting these early immune changes may offer opportunities for early intervention to delay or prevent autoimmunity.
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