Related Experiment Video
Updated: Jun 7, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
Trends in the Mortality Rate of Major Kidney Diseases - China, 2014-2021
Xinhui Yu1, Jinlei Qi1, Peng Yin1
1National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Introduction:
Kidney disease represents a significant public health issue in China, yet there is a lack of comprehensive knowledge regarding national and regional trends in its mortality and causes. This study evaluated the mortality, causes, and regional distribution of major kidney diseases in China from 2014 to 2021.
Methods:
Data pertaining to kidney disease were obtained from the National Death Cause Surveillance System. Estimates were made for both the mortality rates and age-standardized mortality rates (ASMR) for kidney cancer, glomerular disease, tubulointerstitial nephritis, and kidney failure. Additionally, the average annual percent change (AAPC) was calculated to illustrate trends by sex, urban/rural distinctions, and regional differences from 2014 to 2021.
Results:
There was a significant reduction in the ASMR for all kidney diseases combined from 2014 to 2021. Analysis of age-specific mortality rates reveals a gradual increase beginning at age 35, with a sharp rise after age 60. However, the ASMR for glomerular disease and kidney failure in females, as well as for tubulointerstitial nephritis in males, displayed a notable decrease. Regionally, the ASMR for glomerular disease in the eastern region and kidney failure in the western region significantly decreased by AAPC of -4.6% and -2.3%, respectively. Conversely, the ASMR for kidney cancer in the central region rose significantly (AAPC=2.1%).
Conclusion:
From 2014 to 2021, the ASMR for major kidney diseases remained high among men, urban residents, and individuals in western China. Future prevention and control initiatives should prioritize these disparities to mitigate the impact of kidney diseases.
Related Concept Videos
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Internal Anatomy of the Kidney
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Nephrons

