Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electroretinographic recovery from controlled total ischemia.

J R Brunette, P Olivier, P Blondeau

    Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
    |February 1, 1986
    PubMed
    Summary

    Retinal ischemia recovery in animals showed reversed wave amplitude patterns, with hyperresponses and increased delays. Sixty minutes of occlusion served as a threshold for poorer electroretinogram (ERG) recovery.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impact of gestational diabetes mellitus on fetal cardiac morphology and function: cohort comparison of second- and third-trimester fetuses.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2020
    Same author

    Prospective randomized clinical trial on the effects of latanoprost, travoprost and bimatoprost on latanoprost non-responders.

    Journal francais d'ophtalmologie·2019
    Same author

    Assessment of indoor HONO formation mechanisms based on in situ measurements and modeling.

    Indoor air·2016
    Same author

    Identification of the major HO<sub>x</sub> radical pathways in an indoor air environment.

    Indoor air·2016
    Same author

    Long-term follow-up of radiation accident patients in Peru: review of two cases.

    Radiation protection dosimetry·2012
    Same author

    Plasmodium vivax malaria in a Romanian traveller returning from Greece, August 2011.

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2011

    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Physiology

    Background:

    • Retinal ischemia, caused by interrupted blood flow, can lead to vision loss.
    • Understanding the recovery patterns of retinal function after ischemia is crucial for developing effective treatments.
    • Previous studies on electroretinogram (ERG) recovery after retinal ischemia have reported different patterns.

    Purpose of the Study:

    • To investigate the recovery patterns of electroretinograms (ERGs) in animals following varying durations of retinal circulatory occlusion.
    • To compare ERG recovery characteristics with previously reported findings.

    Main Methods:

    • Three groups of animals underwent total occlusion of retinal circulation for 30, 60, or 90 minutes.
    • ERG recordings were taken during a four-hour recovery period post-occlusion.

    Related Experiment Videos

  • Analysis focused on wave amplitude and delay changes during recovery.

    • Main Results:

    • ERG recovery patterns were inversely proportional to ischemia duration.
    • Wave amplitude initially extinguished, then recovered to hyperresponsive levels, reversing previous reports.
    • ERGs exhibited increased delays with longer recovery times, contrary to expectations.
    • Sixty minutes of occlusion emerged as a critical threshold, beyond which ERG recovery was significantly impaired.

    Conclusions:

    • Retinal ischemia recovery exhibits complex, non-linear patterns.
    • The duration of ischemia critically influences the extent and nature of ERG recovery.
    • Sixty minutes of retinal circulatory occlusion represents a threshold for substantial functional deficits, suggesting potential for irreversible damage.