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Synthesis and Comprehensive Characterization of Amino Acid-Derived Vinyl Monomer Gels
Claire Beddok1,2,3, Alicia Zimmer1, Carole Calas Blanchard2,3
1Centre de Recherches Insulaires et Observatoire de l'Environnement, UAR 3278 UPVD-CNRS-EPHE-PSL Labex CORAIL, Université de Perpignan Via Domitia, Perpignan 66860, France.
Abstract:
In this study, we report an easy synthetic pathway to vinyl monomers derivatized with amino acids. Tyrosine-, phenylalanine-, tryptophan-, leucine-, and methionine-based monomers were synthesized, and their polymerization in the presence of cross-linking agents led to the formation of amino acid-based gels. The nature of cross-linker, the time of polymerization, and the type of initiation (photopolymerization or thermopolymerization) were investigated. The obtained gels were characterized using a combination of thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), rheology, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (NMR) spectroscopy. These novel amino acid-based gels could find applications in various areas such as drug delivery, biosensing, and biotechnology.
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