Risk Factors for Secondary Organizing Pneumonia and Acute Fibrinous and Organizing Pneumonia in Patients with COVID-19 Pneumonia
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Older age, diabetes, and low oxygen levels increase the risk of organizing pneumonia (OP) and acute fibrinous and organizing pneumonia (AFOP) in COVID-19 patients. These conditions are linked to higher mortality.
Area Of Science
- Pulmonary Medicine
- Infectious Diseases
- Critical Care
Background
- Secondary organizing pneumonia (OP) and acute fibrinous and organizing pneumonia (AFOP) are common in COVID-19 pneumonia.
- Risk factors and outcomes for OP/AFOP in COVID-19 patients require further clarification.
Purpose Of The Study
- Identify risk factors for OP/AFOP in hospitalized COVID-19 patients.
- Compare clinical outcomes, including 90-day mortality, between patients with and without OP/AFOP.
Main Methods
- Retrospective study of 666 hospitalized COVID-19 patients (July-September 2021).
- Multivariable regression analysis to identify OP/AFOP risk factors.
- Cox proportional hazard model to assess 90-day mortality risk.
Main Results
- 8% of patients developed OP/AFOP.
- Risk factors included age ≥50 years (aOR 3.87-5.74), diabetes mellitus (aOR 2.37), and admission SpO2 <88% (aOR 4.52).
- OP/AFOP associated with increased risk of respiratory failure, AKI, infections, pneumothorax, pneumomediastinum, PE, and significantly higher 90-day mortality (aHR 3.40).
Conclusions
- Age ≥50, diabetes, and hypoxemia are key risk factors for OP/AFOP in COVID-19.
- OP/AFOP significantly increases the risk of severe complications and 90-day mortality in COVID-19 patients.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
The pathophysiology of pneumonia involves the following steps:
• Inhalation of Infectious Agents: Pneumonia typically begins when pathogenic organisms (bacteria, viruses, fungi) are inhaled or aspirated into the lower respiratory tract.
• Overcoming Lung Defenses: Ideally, the respiratory tract has defense mechanisms like mucociliary clearance and cough reflex to prevent the establishment of pathogenic organisms. If these defenses are compromised, or the pathogen is highly...
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
• Pleurisy: indicates the inflammation of the pleura, which causes chest pain and discomfort.
• Pleural Effusion: indicates fluid buildup in the pleural space.
• Atelectasis: Partial collapse of a lung lobe due to mucus blockage or external compression.
• Bacteremia: Bacterial infection entering the bloodstream, commonly seen with...
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
• Inhalation of Irritants: Inhaling irritants, especially cigarette smoke, are primary causes of inflammation in COPD. Other irritants can include...
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
• Chronic Cough: A persistent cough, often productive, is a crucial symptom of COPD.
•...