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Updated: Jun 7, 2025

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

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Published on: February 6, 2021

Haemophilus influenzae Endophthalmitis Associated With Intravitreal Pegcetacoplan Injection.

George Jiao¹, Daniel Zhu¹, Jeffrey L Shakin^1,2

¹Department of Ophthalmology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health Eye Institute, Great Neck, NY, USA.

Journal of Vitreoretinal Diseases

|November 18, 2024

Summary

Intravitreal pegcetacoplan may increase the risk of serious eye infections, such as endophthalmitis caused by encapsulated bacteria like Haemophilus influenzae, particularly in immunocompromised individuals.

Keywords:

bacterial endophthalmitis complement function geographic atrophy immunocompromised pegcetacoplan

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Area of Science:

Ophthalmology
Infectious Diseases
Pharmacology

Background:

Intravitreal injections are common treatments for various eye conditions.
Pegcetacoplan is a complement inhibitor used in treating certain retinal diseases.
Endophthalmitis is a severe intraocular infection that can lead to vision loss.

Purpose of the Study:

To report a case of endophthalmitis following intravitreal pegcetacoplan injection.
To identify the causative organism and potential risk factors.

Main Methods:

A single retrospective case study was conducted.
Clinical data and microbiological findings were analyzed.

Main Results:

An 88-year-old female patient developed endophthalmitis in the right eye after receiving bilateral intravitreal pegcetacoplan injections.
The endophthalmitis was caused by Haemophilus influenzae, an encapsulated bacterium.
The patient also had Proteus mirabilis bacteremia.

Conclusions:

Pegcetacoplan may be associated with an increased risk of intraocular infections, particularly with encapsulated organisms.
Immunocompromised patients receiving pegcetacoplan may be at higher risk.
This case highlights the importance of monitoring for infections after intravitreal pegcetacoplan treatment.