Related Experiment Video

Updated: Jun 7, 2025

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.2K

Lifestyle Intervention Improves Parasympathetic Activity in Hypertrophic Cardiomyopathy

Alaa I Alyahya1,2,3, Sarah J Charman1,2, Nduka C Okwose1,2,4

  • 1Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, UK (AIA, SJC, NCO, ASF, CE, PL, DGJ).

American Journal of Lifestyle Medicine
|November 18, 2024
PubMed

Insights

This study shows that a lifestyle intervention combining physical activity and dietary nitrate supplementation improved heart rate variability and lowered blood pressure in hypertrophic cardiomyopathy patients.

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Nutritional Science

Background:

  • Limited research exists on lifestyle interventions for hypertrophic cardiomyopathy (HCM).
  • This study addresses the need for effective management strategies in HCM.
  • Investigating novel interventions is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate a novel lifestyle intervention for hypertrophic cardiomyopathy (HCM).
  • The intervention combined physical activity (PA) and dietary nitrate supplementation.
  • To assess the impact on heart rate variability (HRV) and hemodynamic measures.

Main Methods:

  • Twenty-eight HCM patients were randomized into intervention and control groups.
  • The intervention group received daily nitrate supplementation and increased PA.
  • HRV and non-invasive hemodynamic variables were measured at baseline and follow-up.

Main Results:

  • The intervention group showed significant increases in high frequency (HF) and low frequency (LF) power of HRV.
  • Resting mean arterial blood pressure (MABP) significantly decreased in the intervention group.
  • No significant changes were observed in the control group.

Conclusions:

  • A novel lifestyle intervention enhanced parasympathetic activity in HCM patients.
  • Dietary nitrate supplementation and PA positively impacted HRV.
  • The intervention effectively reduced resting MABP in individuals with HCM.

Keywords:
haemodynamic functionheart rate variabilityhypertrophic cardiomyopathylifestylenitrate

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.4K
Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy08:34

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

Published on: September 25, 2017

24.3K

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
391
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
2
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
926
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
567
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
739
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
574