Brain state and dynamic transition patterns of motor imagery revealed by the bayes hidden markov model

Motor imagery (MI) is a high-level cognitive process that has been widely applied to brain-computer inference (BCI) and motor recovery. In practical applications, however, huge individual differences and unclear neural mechanisms have seriously hindered the application of MI and BCI systems. Thus, it is urgently needed to explore MI from a new perspective. Here, we applied a hidden Markov model (HMM) to explore the dynamic organization patterns of left- and right-hand MI tasks. Eleven distinct HMM states were identified based on MI-related EEG data. We found that these states can be divided into three metastates by clustering analysis, showing a highly organized structure. We also assessed the probability activation of each HMM state across time. The results showed that the state probability activation of task-evoked have similar trends to that of event-related desynchronization/synchronization (ERD/ERS). By comparing the differences in temporal features of HMM states between left- and right-hand MI, we found notable variations in fractional occupancy, mean life time, mean interval time, and transition probability matrix across stages and states. Interestingly, we found that HMM states activated in the left occipital lobe had higher occupancy during the left-hand MI task, and conversely, during the right-hand MI task, HMM states activated in the right occipital lobe had higher occupancy. Moreover, significant correlations were observed between BCI performance and features of HMM states. Taken together, our findings explored dynamic networks underlying the MI-related process and provided a complementary understanding of different MI tasks, which may contribute to improving the MI-BCI systems.

The online version contains supplementary material available at 10.1007/s11571-024-10099-9.