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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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First Hit the Best Hit for Advanced Differentiated Papillary Thyroid Carcinoma?

Bipin T Varghese1

  • 1Head and Neck Surgery, Department of Surgical Services, Regional Cancer Centre, Thiruvananthapuram, 695011 Kerala India.

Indian Journal of Surgical Oncology
|November 18, 2024
PubMed
Summary

Optimal upfront surgery with precise image mapping can improve outcomes and reduce the need for post-operative radioiodine therapy in differentiated thyroid cancer. Advances in targeted agents and precision medicine now allow surgery even for advanced or inoperable cases.

Keywords:
Advanced differentiated thyroid cancersComprehensive surgeryDual imagingNeoadjuvant targeted therapy

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Nuclear Medicine

Background:

  • Differentiated thyroid cancer (DTC) treatment traditionally involves surgery and radioiodine therapy.
  • Post-operative radioiodine therapy aims to ablate remnant thyroid tissue and treat potential metastases.
  • Minimizing adjuvant therapies like radioiodine is desirable to reduce side effects and long-term risks.

Purpose of the Study:

  • To evaluate the role of upfront surgery with precise image mapping in optimizing DTC treatment outcomes.
  • To explore the potential of reducing or avoiding post-operative radioiodine therapy.
  • To assess the feasibility of surgical intervention for advanced or inoperable DTC using modern therapeutic approaches.

Main Methods:

  • Utilizing precise and objective image mapping techniques for surgical planning and execution.
  • Applying targeted agents and principles of precision medicine in the management of DTC.
  • Performing upfront surgical resection in patients with advanced or inoperable DTC.

Main Results:

  • Precise image-guided surgery enhances treatment outcomes in DTC.
  • Upfront surgical approaches can potentially mitigate the necessity for post-operative radioiodine therapy.
  • Advances enable surgical treatment for previously inoperable advanced DTC.

Conclusions:

  • Optimal upfront surgery with precise image mapping is a promising strategy for DTC.
  • This approach may reduce reliance on post-operative radioiodine therapy.
  • Precision medicine facilitates surgical options for advanced DTC, improving patient management.