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Related Experiment Video

Updated: Jun 7, 2025

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Adamantinoma: A SEER-based Epidemiological Analysis.

Kevin E Agner1, Michael C Larkins2,3

  • 1The Ohio State University College of Medicine, 370 W. 9 Avenue, Columbus, OH 43210 USA.

Indian Journal of Surgical Oncology
|November 18, 2024
PubMed
Summary
This summary is machine-generated.

Younger patients diagnosed with adamantinoma (AD), a rare bone cancer, show improved long-term survival and more localized disease. Age at diagnosis is a key factor influencing outcomes for this rare cancer.

Keywords:
AdamantinomaCancer EpidemiologyPediatric OncologySurgical Oncology

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Area of Science:

  • Oncology
  • Orthopedic Oncology
  • Cancer Epidemiology

Background:

  • Adamantinoma (AD) is an exceptionally rare primary bone malignancy, representing less than 0.5% of all bone tumors.
  • Established treatment guidelines and comprehensive long-term survival data for AD are lacking.
  • Understanding prognostic factors is crucial for improving patient outcomes in rare cancers.

Purpose of the Study:

  • To investigate long-term (20-year) overall survival (OS) in patients diagnosed with adamantinoma.
  • To identify demographic and treatment variables that influence 20-year OS in AD patients.
  • To explore the relationship between age at diagnosis and disease presentation (local vs. distant).

Main Methods:

  • Utilized the Surveillance, Epidemiology, and End Results (SEER) Program database for patient identification.
  • Analyzed data from 74 patients diagnosed with primary adamantinoma (ICD-O-3 code 9261/3).
  • Employed Fisher's Exact Test for demographic and treatment variable analysis and log-rank analysis for 20-year OS assessment.

Main Results:

  • Younger age at diagnosis (<25 years) was significantly associated with increased 20-year overall survival (HR=0.28, p=0.028).
  • Patients over 40 years old at diagnosis had significantly decreased 20-year survival (46%) compared to those 40 or younger (96%, p=0.005).
  • Younger patients (≤40 years) were more likely to present with localized disease (p=0.017), while older patients (>40 years) had a higher proportion of distant disease.

Conclusions:

  • Younger age at diagnosis is a significant positive prognostic factor for long-term survival in adamantinoma.
  • Age influences both survival outcomes and the likelihood of localized versus distant disease presentation.
  • Further population-based studies are needed to overcome limitations of rare cancer data collection and coding.