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Electroanalytical Quantification of DNA Chirality.

A K M Kafi¹, Pravin Pokhrel¹, Hao Shen¹

¹Department of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.

Langmuir : the ACS Journal of Surfaces and Colloids

|November 18, 2024

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This study introduces a new method to quantify DNA chirality using cyclic voltammetry under polarized magnetic fields. This research establishes a unified scale for comparing molecular chirality, with implications for spintronics and molecular recognition.

Area of Science:

Molecular Biophysics
Spintronics
Chirality Studies

Background:

Chirality is crucial for molecular function but lacks experimental quantification methods.
Understanding and measuring molecular chirality is essential for advancements in various scientific fields.

Purpose of the Study:

To develop a unified scale for quantifying and comparing DNA chirality.
To investigate the influence of different factors on molecular chirality using a novel experimental approach.

Main Methods:

Cyclic voltammetry (CV) was employed under polarized magnetic fields.
Electron spin polarization was measured in various DNA structures (duplexes, triplexes).

Main Results:

DNA structures with opposite chiral senses showed the largest electron spin polarization (chiral-induced spin selectivity - CISS).

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Spin polarization varied based on DNA topology, sequence, and electron transport direction.

DNA triplexes exhibited stronger CISS compared to duplexes, with sequence-specific variations observed in duplexes.

Conclusions:

A hierarchical contribution of chiral sense, topology, sequence, and electron transport directionality to molecular chirality was established.
The findings provide a quantitative scale for molecular chirality, impacting spintronics and molecular recognition technologies.