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Related Experiment Video

Updated: Jun 7, 2025

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Published on: November 1, 2024

A Rat Model of Compound Acne.

Lin Chen¹, Qi Jin¹, Tian Xia²

¹Beijing Hospital of Traditional Chinese Medicine, Capital Medical University; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine.

Journal of Visualized Experiments : Jove

|November 18, 2024

Summary

This study successfully created a new rodent model for acne vulgaris by combining oleic acid and Cutibacterium acnes (C. acnes) to induce inflammation, offering a valuable tool for acne research.

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Area of Science:

Dermatology
Microbiology
Animal Models

Background:

Acne vulgaris is a common skin condition.
Existing models do not fully replicate acne's complexity.

Purpose of the Study:

To establish a novel compound rodent model for acne vulgaris.
To simulate key aspects of acne inflammation using oleic acid and C. acnes.

Main Methods:

Rats were divided into four groups: control, oleic acid (OA) only, Cutibacterium acnes (C. acnes) only, and combined OA + C. acnes.
Oleic acid mimicked sebum production, while C. acnes injection induced bacterial inflammation.
Ear thickness, gross observation, histology, and immunohistochemistry (TNF-α) were used to assess inflammation.

Main Results:

The combined OA + C. acnes group showed significant ear thickening, induration, erythema, comedones, papules, and abscesses.
Histopathology revealed hyperkeratinization, follicular infundibulum expansion, and inflammatory cell infiltration.
Immunohistochemistry confirmed elevated tumor necrosis factor-alpha (TNF-α) levels in inflamed ears.

Conclusions:

A compound rodent model effectively simulates acne vulgaris inflammation.
This model provides a robust platform for studying acne pathogenesis and testing therapeutics.