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Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

731
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

121
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Colloidal precipitates01:09

Colloidal precipitates

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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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Updated: Jun 7, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
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Addressing overlooked design considerations for nanoemulsions.

Rafquat Rana1, Kaushik Kuche2, Sanyog Jain2

  • 1Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.

Nanomedicine (London, England)
|November 18, 2024
PubMed
Summary

Nanoemulsions enhance drug delivery by improving solubility and absorption, overcoming lipid barrier challenges. This study revisits nanoemulsion design to address development hurdles and commercial viability for advanced therapeutics.

Keywords:
High energy methodsLow energy methodsNanoemulsionOstwald ripeningSteric stabilization

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Genetic and molecular research offers targeted therapies, but poor solubility and absorption limit drug efficacy.
  • Therapeutic entities struggle to cross lipid barriers, hindering treatment effectiveness.
  • Nanoemulsions are promising lipid-based systems for enhancing bioavailability and reducing toxicity.

Purpose of the Study:

  • To address the gap in understanding nanoemulsion design and development challenges.
  • To reconsider overlooked aspects of nanoemulsion formulation.
  • To provide insights into the commercial viability of nanoemulsion-based drug delivery.

Main Methods:

  • Review of physicochemical properties of nanoemulsions.
  • Analysis of factors influencing nanoemulsion formulation.
  • Evaluation of challenges in nanoemulsion design and development.

Main Results:

  • Nanoemulsions offer improved solubility and absorption for hydrophobic drugs.
  • Key physicochemical properties contribute to enhanced bioavailability and reduced toxicity.
  • Overlooked design aspects can impact nanoemulsion efficacy and commercialization.

Conclusions:

  • Nanoemulsions represent a significant advancement in drug delivery for challenging therapeutic entities.
  • Addressing design and development challenges is crucial for realizing the full potential of nanoemulsions.
  • Further investigation into commercial viability can accelerate the adoption of nanoemulsion technology.