Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Folding01:25

Protein Folding

7.8K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
7.8K
Protein Complex Assembly02:41

Protein Complex Assembly

10.6K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
10.6K
Peptide Bonds02:43

Peptide Bonds

73.1K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
73.1K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

18.2K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
18.2K
Protein Organization01:24

Protein Organization

6.3K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging Design Principles at the Forefront of Mitochondrial Transplantation Using Engineering Methodologies: Current Achievements and Future Directions.

Chemical biology & drug design·2026
Same author

Zwitterion Moieties in Polypeptides Synergistically Enhance the Release of Cellulose and Amorphous Polysaccharides from Plant Cell Walls.

Biomacromolecules·2026
Same author

Resilin-Mimetic Copolypeptides from Minimal Motifs: A Chemoenzymatic and Bioinspired Circular Design for Sustainable Bioelastic Materials.

Biomacromolecules·2026
Same author

Post-translational modifications of silk proteins.

RSC chemical biology·2026
Same author

Spider silk-based structural proteins as tough, biodegradable, and sustainable polymers.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2026
Same author

Unraveling the impact of cyclic peptide primary structure on rotaxane formation through umbrella sampling molecular dynamics simulations.

Physical chemistry chemical physics : PCCP·2026

Related Experiment Video

Updated: Jun 7, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

12.9K

The structural and functional impacts of rationally designed cyclic peptides on self-assembly-mediated functionality.

Taichi Kurita1, Keiji Numata1,2,3

  • 1Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. keiji.numata@riken.jp.

Physical Chemistry Chemical Physics : PCCP
|November 18, 2024
PubMed
Summary

Cyclic peptides offer enhanced stability and function over linear ones. Strategic design of their structure enables precise control over self-assembly, leading to applications in nanotechnology and drug delivery.

More Related Videos

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.6K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K

Related Experiment Videos

Last Updated: Jun 7, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

12.9K
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.6K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K

Area of Science:

  • Peptide chemistry
  • Supramolecular chemistry
  • Materials science

Background:

  • Cyclic peptides exhibit unique topologies, providing superior stability and functionality compared to linear peptides.
  • The rational design of cyclic peptide primary structures is crucial for controlling self-assembly and functional properties.

Purpose of the Study:

  • To comprehensively review the rational design of cyclic peptide primary structures.
  • To emphasize the influence of sequence and ring size on peptide nanotube (PNT) and rotaxane formation.
  • To highlight the role of computational methods in designing tailored cyclic peptides.

Main Methods:

  • Review of literature on cyclic peptide design and self-assembly.
  • Analysis of structure-property relationships in PNTs and rotaxanes.
  • Discussion of computational approaches for predicting cyclic peptide structures.

Main Results:

  • Strategic modification of amino acid sequences and ring sizes precisely dictates PNT diameter, surface properties, and functions.
  • Cyclic peptides demonstrate complex host-guest chemistry, enabling the formation of rotaxanes and mechanically interlocked structures.
  • Computational methods are vital for accurately predicting solution structures and guiding the design of novel cyclic peptides.

Conclusions:

  • The rational design of cyclic peptide primary structures is key to controlling self-assembly and unlocking advanced functionalities.
  • Cyclic peptides hold significant potential for applications in nanotechnology, drug delivery, and materials science.
  • Advances in computational prediction facilitate the development of custom cyclic peptides for diverse applications.