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Study of Protein-protein Interactions in Autophagy Research
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PINK1 controls RTN3L-mediated ER autophagy by regulating peripheral tubule junctions

Ravi Chidambaram1, Kamal Kumar1, Smriti Parashar1

  • 1Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.

The Journal of Cell Biology
|November 18, 2024
PubMed
Summary

Parkinson's disease protein PINK1 shapes the endoplasmic reticulum (ER) for clearing misfolded proteins via ER-phagy. Loss of PINK1 impairs this process, but DRP1 protein can restore it, suggesting therapeutic potential.

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