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Quality of bowel preparation for colonoscopy in patients on glucagon-like peptide-1 receptor agonists
Khushboo Gala1, June Tome1, Mary Krall2
1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Background And Aims:
We aimed to assess the quality of bowel preparation in a matched cohort of patients actively using and not using glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in a large health system in the United States.
Methods:
We performed a retrospective review of adult patients undergoing colonoscopy in 22 endoscopy units across 18 sites in the United States.
Results:
Our cohort comprised 6235 patients (3344 case patients and 2891 control patients). Baseline variables causing suboptimal bowel preparation were setting of procedure (inpatient), sex (male), body mass index (higher), type 2 diabetes mellitus, inflammatory bowel disease, opioid medications, heart failure, and cirrhosis. Total Boston Bowel Preparation Scale was significantly higher in control patients even after controlling for the mentioned variables (P < .01). Case patients were significantly more likely to meet the definition of inadequate bowel preparation. There was no significant difference between different classes of GLP-1 RAs.
Conclusions:
Patients using GLP-1 RAs are more likely to have inadequate bowel preparation during colonoscopy, even accounting for other comorbidities.
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