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Cough-Variant Asthma: A Review of Clinical Characteristics, Diagnosis, and Pathophysiology
Joshua K Cox1, Richard Lockey1, Juan Carlos Cardet1
1Division of Allergy and Immunology, University of South Florida, Tampa, Fla.
Abstract:
Chronic cough is among the most common symptoms prompting medical care. Cough-variant asthma (CVA) is an asthma subset where cough is the primary symptom, without wheezing, chest tightness, or dyspnea. It is an important cause of chronic cough, estimated to account for 25% to 42% of cases, but likely underdiagnosed due to delayed recognition and pitfalls of diagnostic testing. Early recognition and treatment can reduce morbidity and delay its progression to more typical asthma. This review details the clinical characteristics, diagnosis, pathophysiology, and treatment of CVA and contrasts it with classic asthma and other causes of chronic cough.
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