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Published on: June 13, 2014
Signalling and molecular pathways, overexpressed receptors of colorectal cancer and effective therapeutic targeting
Sandip Dey1, Manik Ghosh1, Abhimanyu Dev1
1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Jharkhand, India.
Abstract:
Increasing morbidity and mortality in CRC is a potential threat to human health. The major challenges for better treatment outcomes are the heterogeneity of CRC cases, complicated molecular pathway cross-talks, the influence of gut dysbiosis in CRC, and the lack of multimodal target-specific drug delivery. The overexpression of many receptors in CRC cells may pave the path for targeting them with multiple ligands. The design of a more target-specific drug-delivery device with multiple ligand-functionalized, green-synthesized silver nanoparticles is highly promising and may also deliver other approved chemotherapeutic agents. This review presents the various aspects of colorectal cancer and over-expressed receptors that can be targeted with appropriate ligands to enhance the specific drug delivery potency of green synthesised silver nanoparticles. This review aims to broaden further research into this multi-ligand functionalised, safer and effective silver nano drug delivery system.
Insights
Green-synthesized silver nanoparticles functionalized with multiple ligands offer a promising approach to target colorectal cancer (CRC) more effectively. This novel drug delivery system aims to overcome CRC treatment challenges and improve patient outcomes.
Area of Science:
- Nanomedicine
- Oncology
- Materials Science
Background:
- Colorectal cancer (CRC) presents significant morbidity and mortality due to its heterogeneity, complex molecular pathways, gut dysbiosis influence, and lack of targeted drug delivery.
- Overexpressed receptors on CRC cells present opportunities for targeted therapies using multiple ligands.
- Current CRC treatments face challenges in specificity and efficacy.
Purpose of the Study:
- To review the potential of green-synthesized silver nanoparticles (AgNPs) functionalized with multiple ligands for targeted colorectal cancer drug delivery.
- To explore the targeting of overexpressed receptors on CRC cells using specific ligands attached to AgNPs.
- To highlight the promise of this multi-ligand functionalized AgNP system for enhancing drug delivery potency and efficacy.
Main Methods:
- Review of existing literature on colorectal cancer, receptor overexpression, ligand targeting, and green synthesis of silver nanoparticles.
- Analysis of the design principles for multi-ligand functionalized nanoparticles for targeted drug delivery.
- Discussion of the potential for incorporating approved chemotherapeutic agents into the silver nanoparticle system.
Main Results:
- Green-synthesized silver nanoparticles can be functionalized with multiple ligands to target specific receptors overexpressed in colorectal cancer.
- This approach offers a strategy to overcome the limitations of current CRC treatments, including heterogeneity and lack of specificity.
- The multi-ligand functionalized AgNPs show promise for enhanced delivery of chemotherapeutic agents directly to cancer cells.
Conclusions:
- Multi-ligand functionalized, green-synthesized silver nanoparticles represent a promising and safer nano drug delivery system for colorectal cancer.
- This targeted approach has the potential to improve treatment outcomes by enhancing drug delivery potency.
- Further research into this advanced silver nano drug delivery system is warranted to fully realize its therapeutic potential.
