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Sleep Disorders Five Years After Acute Provoked Neonatal Seizures
Renée A Shellhaas1, Linda S Franck2, Betsy Pilon3
1Department of Neurology, Washington University School of Medicine, St Louis, MO.
The Journal of Pediatrics
|November 18, 2024
Summary
Abnormal sleep is common in children who survived neonatal seizures, affecting two-thirds of survivors. Addressing sleep issues may improve long-term outcomes for these children and their parents.
Area of Science:
- Pediatric Neurology
- Sleep Medicine
- Developmental Pediatrics
Background:
- Neonatal seizures can have long-term consequences for child development.
- Sleep disturbances are increasingly recognized as a potential adverse outcome in pediatric populations.
- Understanding the impact of sleep on survivors of neonatal seizures is crucial for comprehensive care.
Purpose of the Study:
- To investigate the association between abnormal sleep and adverse outcomes in children who survived acute provoked neonatal seizures.
- To assess the prevalence of sleep abnormalities and sleep-disordered breathing (SDB) in this cohort.
- To examine the relationship between sleep problems and neurodevelopmental, behavioral, and parental mental health outcomes.
Main Methods:
- A prospective, 9-center study followed newborns with acute provoked seizures.
- At age 5 years, children underwent cognitive assessments (WPPSI-IV) and functional evaluations (Vineland-3).
- Parents completed questionnaires on child sleep habits (CSHQ), sleep-related breathing disorders (PSQ-SRBD), and their own anxiety and depression levels.
Main Results:
- 65% of children had abnormal sleep habits (CSHQ score > 41) and 27% screened positive for SDB.
- SDB was more prevalent in children with cerebral palsy and epilepsy.
- Lower cognitive (WPPSI-IV) and adaptive behavior (Vineland-3) scores were associated with SDB symptoms.
- Poor sleep quality and SDB symptoms correlated with increased parental anxiety and depression.
Conclusions:
- Parent-reported sleep abnormalities and SDB are common in early school-aged survivors of neonatal seizures.
- Sleep disorders in this population are linked to poorer neurodevelopmental and behavioral outcomes.
- Implementing early screening and treatment for sleep disorders could significantly improve outcomes for children post-neonatal seizures.
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