Related Experiment Video
Updated: Jun 7, 2025
09:01
Chronic Salmonella Infected Mouse Model
Published on: May 31, 2010
17.3K
Antibiotic-recalcitrant Salmonella during infection
Rachel T Giorgio1, Sophie Helaine2
1Department of Microbiology, Harvard Medical School, Boston, MA, USA.
Nature Reviews. Microbiology
|November 18, 2024
Summary
Antibiotic-recalcitrant infections involve prolonged bacterial presence despite antibiotic use. Understanding these infections, particularly with Salmonella, is crucial for preventing relapse and combating antimicrobial resistance.
Area of Science:
- Microbiology
- Infectious Diseases
- Immunology
Background:
- Antibiotic-recalcitrant infections are characterized by persistent pathogenic bacteria despite antibiotic treatment.
- These infections are often caused by genetically susceptible bacteria that survive antibiotic exposure and can recolonize.
- Antibiotic-recalcitrant Salmonella are implicated in infection relapse and contribute to antimicrobial resistance spread.
Purpose of the Study:
- To review current knowledge on antibiotic recalcitrance in Salmonella during infection.
- To identify knowledge gaps and areas for future research.
Main Methods:
- This is a review article, synthesizing existing research.
- Literature search and analysis of studies on antibiotic-recalcitrant bacteria, focusing on Salmonella.
Main Results:
- Antibiotic recalcitrance allows bacteria to persist and potentially cause infection relapse.
- Recalcitrant bacteria can manipulate host immune responses.
- These bacteria play a role in the dissemination of antimicrobial resistance.
Conclusions:
- Further research is needed to fully understand the mechanisms of antibiotic recalcitrance in Salmonella.
- Addressing antibiotic recalcitrance is vital for effective infection control and combating antimicrobial resistance.
Related Concept Videos
00:57Antibiotic Selection
52.3K
Overview
52.3K
01:30Development of Antibiotic Resistance
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...