Related Experiment Video

Updated: Jun 7, 2025

Multimodality Diagnosis of Mesenteric Ischemia
05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

539

Association of celiac disease and myocardial infarction: a systematic review and meta-analysis

Nikhil Sharma1,2, Muhammed Shabil3,4, Mahalaqua Nazli Khatib5

  • 1Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Guwahati, 781101, India.

BMC Cardiovascular Disorders
|November 18, 2024
PubMed

Insights

This meta-analysis found no significant link between celiac disease (CD) and myocardial infarction (MI). Further research is needed due to study heterogeneity and to explore cardiovascular risks in CD patients.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Epidemiology

Background:

  • Celiac disease (CD) is an autoimmune disorder triggered by gluten, primarily impacting the gut but with potential cardiovascular implications.
  • Emerging evidence suggests a link between CD and myocardial infarction (MI), yet existing studies present conflicting findings.
  • This study systematically reviewed and meta-analyzed data to determine the risk of MI in individuals diagnosed with CD.

Approach:

  • A comprehensive literature search was conducted across major databases (PubMed, Embase, Web of Science) up to August 2024.
  • Included studies focused on the association between CD and MI in adult populations, extracting relevant effect estimates.
  • A random-effects meta-analysis was performed using R software to calculate pooled hazard ratios (HRs) and odds ratios (ORs), assessing statistical heterogeneity.

Key Points:

  • The meta-analysis included 8 studies, examining the association between celiac disease and myocardial infarction.
  • Pooled HR analysis (HR=1.143, 95% CI: 0.619-2.109) and OR analysis (OR=0.879, 95% CI: 0.481-1.606) showed no statistically significant association.
  • High heterogeneity was noted across studies (I²=86% for HR, 99% for OR), indicating significant variability in results.

Conclusions:

  • This meta-analysis did not find a significant association between celiac disease and myocardial infarction.
  • Substantial heterogeneity across studies underscores the need for larger, more homogeneous cohorts to clarify cardiovascular risks in CD patients.
  • Future research should investigate specific subgroups and the influence of gluten-free diet adherence on cardiovascular outcomes in individuals with CD.
Abstract

Keywords:
Cardiovascular diseaseCeliac diseaseMeta-analysisMyocardial infarction

More Related Videos

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

7.7K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.7K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
2
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
3
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
7
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
712
Myocarditis II: Clinical features and Diagnostic Tests01:27

Myocarditis II: Clinical features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
2
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
2