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USP11 promotes lipogenesis and tumorigenesis by regulating SREBF1 stability in hepatocellular carcinoma

  • 0Department of Oncology, The Second Affiliated Hospital, Jiangxi Medcical College, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Cell Communication and Signaling : Ccs +

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November 19, 2024

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November 19, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Ubiquitin-specific protease 11 (USP11) promotes hepatocellular carcinoma (HCC) metastasis by enhancing SREBF1-induced lipogenesis. Targeting this pathway offers a new therapeutic strategy for HCC treatment.

Area Of Science

  • Oncology
  • Molecular Biology
  • Cancer Metabolism

Background

  • Hepatocellular carcinoma (HCC) metastasis is linked to altered cancer metabolism.
  • Ubiquitin-specific protease 11 (USP11) is implicated in cancer, but its role in HCC metabolism is unclear.

Purpose Of The Study

  • To elucidate the mechanism by which USP11 influences HCC metastasis via cancer metabolism.
  • To investigate the role of USP11 in regulating lipogenesis in HCC.

Main Methods

  • Identified USP11 as the deubiquitinase for SREBF1 using mass spectrometry and co-immunoprecipitation.
  • Assessed lipogenesis, HCC cell proliferation, migration, and invasion in vitro and in vivo.
  • Utilized xenograft models to validate the USP11/SREBF1 axis in lipogenesis and tumor growth.

Main Results

  • USP11 directly deubiquitinates and stabilizes SREBF1, promoting lipogenesis.
  • USP11 enhances HCC cell proliferation, migration, and invasion.
  • Elevated USP11 and SREBF1 expression correlates with poor HCC prognosis.

Conclusions

  • USP11 promotes HCC proliferation and metastasis by inducing SREBF1-mediated lipogenesis.
  • The USP11/SREBF1 axis represents a potential therapeutic target for HCC treatment.

Keywords:

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