Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploration of the radiation dose-toxicity relationship for multiple ophthalmological organs at risk for pediatric patients assessed in long-term head and neck rhabdomyosarcoma survivors.

Clinical and translational radiation oncology·2026
Same author

Impact of distribution campaigns on the use and availability of long-lasting insecticide-treated nets in rural Guinea.

MalariaWorld journal·2026
Same author

Adaptive radiotherapy incident-informed team training: a development and feasibility study.

Technical innovations & patient support in radiation oncology·2026
Same author

Teaching Novices Ultrasound-Assisted Neuraxial Procedures Using Simulation-Based Courses: A Proof of Concept.

The journal of education in perioperative medicine : JEPM·2026
Same author

Effect of catheter advancement technique on needle tip motion during peripheral intravenous insertion.

The journal of vascular access·2026
Same author

PET-CT benchmarked detection and 5-year progression of asymptomatic tuberculosis: a longitudinal, prospective cohort study.

The Lancet. Respiratory medicine·2026

Related Experiment Video

Updated: Jun 7, 2025

Author Spotlight: Segmentation and VR for Advanced Neurovascular Interventions
06:18

Author Spotlight: Segmentation and VR for Advanced Neurovascular Interventions

Published on: April 5, 2024

966

First-in-human trial using mixed-reality visualization for patient setup during breast or chest wall radiotherapy.

Perry B Johnson1,2, Julie Bradley3,4, Samsun Lampotang3

  • 1University of Florida Health Proton Therapy Institute, Jacksonville, FL, USA. PBJohnson@floridaproton.org.

Radiation Oncology (London, England)
|November 19, 2024
PubMed
Summary

Mixed-reality (MixR) visualization is feasible for patient setup in breast and chest wall radiotherapy, showing comparable accuracy to 3-point alignment. Further development is needed to match surface-guided radiotherapy systems.

Keywords:
Breast radiotherapyHoloLens 2Mixed-realitySurface-guided radiotherapy

More Related Videos

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
06:03

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

6.6K
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

46.7K

Related Experiment Videos

Last Updated: Jun 7, 2025

Author Spotlight: Segmentation and VR for Advanced Neurovascular Interventions
06:18

Author Spotlight: Segmentation and VR for Advanced Neurovascular Interventions

Published on: April 5, 2024

966
Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
06:03

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

6.6K
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

46.7K

Area of Science:

  • Medical Physics
  • Radiotherapy Technology
  • Clinical Trials

Background:

  • Assessing the feasibility of mixed-reality (MixR) visualization for patient positioning in breast and chest wall radiotherapy.
  • Conducting a first-in-human clinical trial to compare MixR with traditional 3-point alignment techniques.

Purpose of the Study:

  • To evaluate the clinical feasibility and accuracy of mixed-reality (MixR) visualization for patient setup in breast and chest wall radiotherapy.
  • To compare the performance of MixR visualization against a standard 3-point alignment method in a real-world clinical setting.

Main Methods:

  • A first-in-human clinical trial involving 18 patients (10 proton, 8 photon RT) for breast or chest wall treatments.
  • Each patient received MixR visualization for five fractions and 3-point alignment for five fractions, with alignment accuracy assessed via cone-beam CT and kV/kV imaging.
  • Registration time and image-guided radiotherapy (IGRT) utilization were recorded during the setup process.

Main Results:

  • In proton therapy, mean 3D shifts were 0.96 cm (3-point) and 1.18 cm (MixR), with equivalence demonstrated (<0.5 cm difference).
  • In photon therapy, mean 3D shifts were 1.18 cm (3-point) and 1.00 cm (MixR), with equivalence demonstrated (<0.3 cm difference).
  • Minor variations were observed in registration time and IGRT use between the two methods.

Conclusions:

  • Mixed-reality (MixR) visualization is a feasible option for patient setup in breast cancer radiotherapy, achieving accuracy and efficiency comparable to 3-point alignment.
  • Further advancements in marker tracking, feedback mechanisms, and understanding perceptual challenges are necessary for MixR to match the accuracy of modern surface-guided radiotherapy (SGRT) systems.