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A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
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Mechanochemically facilitated silver-catalyzed direct H/D exchange on heteroarenes

Yun Jia1,2, Zhi-Jiang Jiang2, Jiawei Han2,3

  • 1School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, P. R. China. hanyf@zstu.edu.cn.

Organic & Biomolecular Chemistry
|November 19, 2024
PubMed
Summary

Mechanochemistry enables direct hydrogen/deuterium (H/D) exchange in insoluble polyarenes. This silver-catalyzed process uses heavy water and grinding, overcoming challenges in deuterating these complex molecules.

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