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Updated: Jun 7, 2025

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Advances in the Understanding of the Pathogenesis of Triple-Negative Breast Cancer
Yuhan Liu1, Yuhan Zou1, Yangli Ye2
1School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
Background:
Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by high aggressiveness, high malignancy, and poor prognosis compared to other breast cancer subtypes.
Objective:
This review aims to explore recent advances in understanding TNBC and to provide new insights and potential references for clinical treatment.
Methods:
We examined current literature on TNBC to analyze molecular subtypes, genetic mutations, signaling pathways, mechanisms of drug resistance, and emerging therapies.
Results:
Findings highlight key aspects of TNBC's molecular subtypes, relevant mutations, and pathways, alongside emerging treatments that target drug resistance mechanisms.
Conclusion:
These insights into TNBC pathogenesis may help guide future therapeutic strategies and improve clinical outcomes for patients with TNBC.
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