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Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
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An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
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Resmetirom.

Terri L Levien1, Danial E Baker2

  • 1Pharmacotherapy Department, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.

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Summary
This summary is machine-generated.

The Formulary Monograph Service provides monthly drug monographs for Pharmacy and Therapeutics Committees, aiding in drug evaluation and utilization. Subscribers receive comprehensive reviews and customizable online access for informed decision-making.

Keywords:
drug informationformulary management/P&Tmetabolic/endocrine

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Area of Science:

  • Pharmaceutical sciences
  • Clinical pharmacy
  • Health services research

Background:

  • Pharmacy and Therapeutics Committees require timely, evidence-based drug information.
  • New drug approvals and late-stage trials necessitate thorough evaluation.
  • Effective medication use evaluation (MUE) is crucial for patient safety and cost-effectiveness.

Purpose of the Study:

  • To provide Pharmacy and Therapeutics Committees with detailed monographs on new and emerging drugs.
  • To offer concise summaries for pharmacy and nursing in-services and agenda planning.
  • To deliver comprehensive drug utilization evaluations (DUE/MUE) to support informed prescribing and formulary management.

Main Methods:

  • Publication of 5-6 detailed monographs per month covering newly released or late-phase III trial drugs.
  • Inclusion of 1-page summary monographs for quick reference and educational purposes.
  • Provision of a comprehensive drug utilization evaluation/medication use evaluation (DUE/MUE) monthly.

Main Results:

  • Subscribers receive consistent, well-documented drug information.
  • Monographs are accessible online, with options for customization.
  • Selected reviews are published in cooperation with Hospital Pharmacy.

Conclusions:

  • The Formulary Monograph Service effectively supports evidence-based formulary management.
  • It provides essential tools for Pharmacy and Therapeutics Committees and healthcare professionals.
  • The service facilitates informed decision-making regarding drug selection and utilization.