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Disease Modification in Asthma: Are We on the Right Way? A Multidisciplinary Expert Delphi Consensus (MODIASTHMA
Juan Carlos Miralles-López1,2, Francisco J Alvarez-Gutiérrez3, Julio Delgado-Romero4
1Allergy Department, University General Hospital Reina Sofia, Murcia, Spain.
Journal of Asthma and Allergy
|November 19, 2024
Summary
Experts reached consensus on key aspects for modifying severe asthma, focusing on clinical, functional, and pathophysiological factors. This agreement is crucial for advancing asthma management strategies and developing new therapeutic targets.
Area of Science:
- Pulmonology
- Allergology
- Pediatrics
Background:
- Emerging biological therapies prompt new asthma management targets, including disease modification.
- Defining "disease modification" in asthma requires scientific consensus.
- Current definitions lack standardization, hindering therapeutic advancement.
Purpose of the Study:
- To establish agreed-upon definitions for disease modification in asthma management.
- To identify essential criteria and indicators for achieving disease modification in asthma.
- To facilitate the development of novel therapeutic strategies for severe asthma.
Main Methods:
- A multidisciplinary expert panel (192 specialists) was convened.
- A systematic literature review informed statement development.
- A Delphi methodology with a 9-point Likert scale assessed 22 statements on disease modification criteria.
Main Results:
- All 22 statements achieved high consensus (median score >7) in the first round.
- Pneumologists, allergologists, and pediatricians unanimously agreed on essential criteria.
- The study successfully identified key clinical-functional and pathophysiological aspects for disease modification.
Conclusions:
- This Delphi study established expert consensus on defining disease modification in asthma.
- Agreement was reached on crucial clinical, functional, and pathophysiological aspects.
- These findings provide a foundation for advancing asthma management and therapeutic development.
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