Multifaced roles of adipokines in endothelial cell function

Area of Science:

• Endocrinology
• Cardiovascular Medicine
• Molecular Biology

Background:

• Obesity is a major risk factor for cardiovascular diseases (CVDs) and mortality.
• Atherosclerosis, a key CVD process, begins with vascular endothelial dysfunction.
• Adipokines, secreted by adipose tissue, critically influence endothelial function.

Purpose of the Study:

• To comprehensively review the roles of various adipokines in endothelial function during atherosclerosis.
• To categorize adipokines as protective or detrimental in this context.
• To explore adipokine-targeting strategies for atherosclerosis treatment.

Main Methods:

• Literature review of scientific studies on adipokines and endothelial function.
• Categorization of adipokines based on their effects on vascular endothelium.
• Analysis of the pathogenic mechanisms linking adipokines to atherosclerosis.

Main Results:

• Adipokines significantly modulate endothelial function in atherosclerosis.
• Protective adipokines include adiponectin, FGF21, CTRP9, PGRN, Omentin, and Vaspin.
• Detrimental adipokines include leptin, Chemerin, Resistin, and FABP4.

Conclusions:

• Adipokines play dual roles in regulating endothelial function in atherosclerosis.
• Targeting specific adipokines presents a promising therapeutic avenue for atherosclerosis-related CVDs.
• This review provides a theoretical basis for developing novel cardiovascular disease treatments.