Comparison of Eosinophil Profile and Lund Kennedy Score in Patients with Nasal Polyps

Nasal polyps are epithelial and stromal non-neoplastic proliferations of nasal cavity and paranasal sinuses. Nasal polyps are a consequence of damage in the epithelium of the nasal mucosa. Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially responsible for the etiopathogenesis and prognosis of the disease. This cross-sectional observational study was conducted in the department of ENT, H&NS, Government Medical College, Srinagar. A total of 62 patients were included in the study. The recorded data was compiled and entered in a spreadsheet (Microsoft Excel) and then exported to data editor of SPSS Version 20.0 (SPSS Inc., Chicago, Illinois, USA). A total of 62 patients participated in the study. Majority of subjects were in the age group of 60-69 and the least number in 20-29. 47 patients had a mean lund kennedyscore of 13.34 ± 1.178 with peripheral eosinophil count of ≥ 500 and 15 patients had a score of 7.00 ± 0.632 with peripheral eosinophil count of < 500. 50 patients had a mean lund kennedy score of 13.04 ± 1.359 with tissue eosinophil count of ≥ 10/HPF and 12 patients had a score of 7.16 ± 0.669 with atissue eosinophil count of < 10/HPF. The conducted study indicates that the levels of tissue and peripheral osinophils are positively related to severity of nasal polyps as indicated by Lund Kennedy scores. Also, our study concluded that the disease has male preponderance.